Audio/Signal Path? Help!

Please Help!
The ManyCam Signal Path is not working in any manner that I understand.
I have been through all of the audio tutorials many times (no pun). And I have no clue why I have audio latency. I have muted devices, turned off global etc etc.

The person viewing my stream sees no issue with video/audio sync, it is me. I see a huge lag in video and audio, even when not streaming. I cannot record audio to a recording etc.

Any help appreciated. I have been running ProTools for 15 years. I currently run a 30 analog input RME UFX, tied with word clock, fed by ADAT lightpipe 16 channels, with a 16 channel headphone mix system via lightpipe on a 2010 MacPro. This is a very involved system and I have no latency issues as I always set a correct buffer size in ProTools.
I do not believe that I should be experiencing any issues with ManyCam, stereo mix 720p 24F on this machine Model Name: MacBook Pro
Model Identifier: MacBookPro11,3
Processor Name: Intel Core i7
Processor Speed: 2.8 GHz
Number of Processors: 1
Total Number of Cores: 4
L2 Cache (per Core): 256 KB
L3 Cache: 6 MB
Memory: 16 GB